There is no specific "diet" for people with factor V Leiden, but there are foods that can help keep your blood and body healthy, which may reduce your risk of developing a blood clot. Healthy fats: Eat healthy fats each day such as olive oil, nuts, seeds and avocado. Fiber (whole-grain cereal, beans, wild rice, flourless wheat bread. That's important because high blood pressure can damage blood vessels, increasing blood clot risk. 3. "Anticoagulant Food-Drug Interactions". on this website is designed to support, not to replace the relationship
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Factor V Leiden This change causes factor V to resist the actions of other proteins (protein C and protein S), which normally inactivate factor V when needed to keep your blood from clotting abnormally. Did I get the mutation from both parents or just one? Want to talk about Multiple Myeloma: Anyone else? The Factor V Leiden protein is harder to turn off than the normal Factor V protein. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. ABSTRACT: Factor V Leiden thrombophilia is a genetic disorder that may increase a patient's risk of developing a venous thromboembolism (VTE). You have 1 Factor V Leiden gene from one parent and 1 normal Factor V gene from your other parent.
PDF Factor V Leiden - Blood Clots These precautions might include: Some precautions to help reduce your risk of blood clots include: If your factor V Leiden requires you to take anticoagulant medication, here are some steps that might help you prevent injury and avoid excessive bleeding: Your doctor may refer you to a specialist in genetic disorders (geneticist) or a specialist in blood disorders (hematologist) for testing to determine whether the cause of your blood clots is genetic and, specifically, whether you have factor V Leiden. The majority of people born with this mutation will not develop an abnormal blood clot in their lifetime. HW}Wc)h"Y$ x N,@I)T7;&?/s"C0]=wSb;{PlYdA&Trb"agbH0Hok8bio@k'q A. Retrieved on March 04, 2023 from https://www.news-medical.net/health/Anticoagulant-Food-Drug-Interactions.aspx. Accessed June 4, 2018. Effective measures to eliminate or reduce other risk factors for DVT or PE, such as smoking cessation, weight loss and having a more active lifestyle. Your provider will advise you on whether you need testing, as well as on the pros and cons of testing. But if you do, prompt treatment can manage your condition. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, (https://medlineplus.gov/genetics/condition/prothrombin-thrombophilia/#resources). Zoppi, Lois. Here are a few to help you start the conversation: Factor V is a coagulation factor, or protein, in your blood. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. In a worst-case scenario, it lands in your legs, leading to deep vein thrombosis, or your lungs, forming a pulmonary embolism. But its important that these individuals discuss with their doctors what they should be aware of and what they can do to minimize the risk of DVT or PE. For children with one affected gene, the chance of getting a blood clot increases 10 times. If you are heterozygous, theres a 50% chance that your children will get the mutation. When taken with anticoagulants, binge-drinking alcohol can increase INR values. Is an uncertain result possible, and what would that mean? Factor V Leiden doesnt affect life expectancy in most people. The mutation does not cause any symptoms in and of itself. In your body, you have 100% of Factor V Leiden and no normal Factor V. This happens in less than 1 out of 100 people. Your doctor may suspect factor V Leiden if you've had one or more episodes of abnormal blood clotting or if you have a strong family history of abnormal blood clots. xb```eB cg`a!OF'96L``XkeWp)8MenQLe*.,j(bicIgBvMS &"T$T'da[[N(~vS$ECp^e ^Ve'/ Get useful, helpful and relevant health + wellness information. Limited sodium: Get less than 2,300 mg of sodium daily, per the American Heart Association. Diseasemaps 2023, FACTORV LEIDEN AND LIVEDOID VASCULOPATHY SURVIVOR. Your doctor can tell you how much fluid is right for your age, health and activity level. Yes, you may be able to donate blood if youre not taking a blood thinner. It is important to discuss potential interactions between existing and new medications to prevent or recognize any side effects. The best diet to follow is one full of foods that support heart health, because these are also naturally good for your blood health. Factors that increase this risk include: Factor V Leiden can cause blood clots in the legs (deep vein thrombosis) and lungs (pulmonary embolism). If youre taking warfarin, youll need routine blood testing (prothrombin time test) to check how well your medication is working. When anticoagulants are prescribed, a prothrombin time (PT) test is used to evaluate its effectiveness. Complex carbohydrates (vegetables, sweet potato, wild rice, beans, lentils, oatmeal, quinoa). A blood test (called a screening test) can show if you have Activated Protein C resistance. Your provider may think you have a clotting problem if you: There is no specific treatment for the mutation itself. In: Williams Hematology. You will most likely not have a dangerous blood clot, but your provider can provide counseling on how to reduce the risk of a deep vein thrombosis or pulmonary embolism. News-Medical. Youll spend roughly the same amount on groceries if you keep the bulk of your protein purchases to eggs, lean meats and poultry, and fat-free dairy, as opposed to seafood. Factor V Leiden is the most common inherited condition that causes an increase in blood clotting. Factor V Leiden. 1-ranked heart program in the United States. If you get the mutation from one of your parents, you are heterozygous (you have only one abnormal copy of the Factor II gene, but the gene from your other parent is normal). Calorie counting is not a feature of this diet plan. This field is for validation purposes and should be left unchanged.
Prothrombin Gene Mutation (Factor II) - Cleveland Clinic Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. What measures are in place to protect my privacy? Because factor V Leiden is a blood clotting condition, you need to have a discussion with your health care team about your dietary restrictions if you are on a blood-thinning medication like warfarin. Factor V and other proteins work together to help your blood clot when necessary. The risks of food-drug interactions include preventing the proper working of a medication, causing unwanted side effects, and changing the way the body uses ingested food or beverages while on the medication. Large amounts of garlic, ginger, glucosamine (an amino sugar), ginseng, and ginkgo should be avoided while on anticoagulant medications as they may increase the risk of bleeding. But some factors raise your risk of developing clots. National Heart, Lung, and Blood Institute. As a result, clotting goes on longer than usual. Recurrent fetal loss during the second or third trimester suggests an inherited thrombophilia or antiphospholipid antibody. Anticoagulant Food-Drug Interactions. Factor V Deficiency Vs. Thank you to @angiodynamics one of our corporate sponsors for the 100,000 Reasons Challenge for their support during #BCAM2023. .wpcdt-timer-24806 .wpcdt-clock .wpcdt-lbl{color: #ffffff;}.wpcdt-timer-24806 .wpcdt-clock-circle span, A mutation in your F5 gene causes this disorder, which follows an autosomal dominant inheritance pattern. Symptoms of a deep vein thrombosis or pulmonary embolism typically start getting better soon after specific treatment is started. The liver is responsible for breaking down alcohol and some medications, and this may cause a slower than normal metabolism of the anticoagulant, increasing the drug concentration in the blood, and hence the risk of bleeding. (https://www.stoptheclot.org/learn_more/prothrombin-g20210a-factor-ii-mutation-links/), (https://www.merckmanuals.com/home/blood-disorders/excessive-clotting/excessive-clotting?query=prothrombin%20gene%20mutation). A family history of factor V Leiden increases your risk of inheriting the disorder. But you will have to be careful about how much fat and salt you are eating, as well, if you were told to limit them in your diet. Lose weight (if you have overweight/obesity). The length of treatment may vary depending on your situation. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Yes, those living with factor v Leiden should avoid any foods that contain a high level of vitamin K. (Green leafy vegetables are a big one). Everyone is born with two copies of the factor V pronounced factor five gene. Middeldorp S, Coppens M. Hereditary Thrombophilia. AskMayoExpert. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. Clots can form in the veins near your bones that carry a lot of blood (deep veins), a condition called deep vein thrombosis. pph~~&"V: 9EP. This disorder affects factor V, as opposed to other proteins in your blood. How does prothrombin gene mutation affect my body? It is not a disease. At this time, we cant treat or change our genes. 0000006483 00000 n
Exercise: Required. Drink plenty of fluids (without alcohol). These include deep vein thrombosis, factor V Leiden, myocardial infarction, and polycythemia vera, among many others. If excess vitamin K is taken, it is stored for future use in the liver. %PDF-1.5
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Symptoms of a blood clot depend on what part of your body is affected. Cost: Just your groceries. Although the prothrombin gene mutation is the second most common inherited predisposition to a deep vein thrombosis or pulmonary embolism, it is the weakest of all inherited clotting disorders in terms of risk of causing abnormal blood clots. Factor V is a protein that is needed for blood to clot properly. Both men and women can have factor V Leiden. Keep going to your follow-up appointments with your provider, especially if youre taking a blood thinner. The sooner you receive care, the better your chances of a good outcome. Since factor V Leiden is a risk for developing blood clots in the leg or lungs, the first indication that you have the disorder may be the development of an abnormal blood clot. https://rarediseases.info.nih.gov/diseases/6403/factor-v-leiden-thrombophilia. Whole grains: Choose whole grains like whole-grain bread, quinoa, farro and brown rice rather than refined grains, such as white bread, white rice, crackers and baked goods made with white flour. But theres no clear consensus, and researchers continue to explore what risks, if any, factor V Leiden poses during pregnancy. The Best Foods to Eat for Promoting Healthy Cells, Your 4-Week Mediterranean Diet Meal Plan, Curated by a Dietitian-Chef, Ready to Try the DASH Diet? If you have kidney disease, there may be too much protein in this diet for you.
Symptoms and causes - Mayo Clinic 2005 - 2023 WebMD LLC. Pasternak promises that eating a balanced meal five times a day will keep your blood sugar low and stable. 9th ed. When enough fibrin has been made, a substance called activated protein C (APC) inactivates factor V, helping stop the clot from growing any larger than necessary. You may be treated with blood thinners during this time. Will Eating More Protein Help Your Body Gain Muscle Faster? News-Medical. Make a donation. A single copy of these materials may be reprinted for noncommercial personal use only. This content does not have an English version. 0000237253 00000 n
However, you can reduce your risk of a deep vein thrombosis or pulmonary embolism if you: The majority of people who have the prothrombin gene mutation dont get a dangerous blood clot and the mutation doesnt cause deep vein thrombosis or pulmonary embolism in the vast majority of pregnancies. you have a medical emergency, call 911 immediately. Accessed June 4, 2018. 2019. https://www.uptodate.com/contents/search. Factor V Leiden is also known under its other name Factor V Leiden Thrombophilia. What's more, they can help lower blood pressure. The exercise portion of the program might have to be changed if you are trying to follow the exercise guidelines of the American Heart Association. Other things can add to your blood clot risk, including: Youll need a specific blood test to check for the prothrombin gene mutation. Carbohydrates with lower glycemic index (GI) values raise blood sugar levels less than foods with a higher GI, but their use in weight loss has not been as well studied. Fish oils may increase a patients INR level, and as such INR levels should be checked if a patient on anticoagulants begins to take significantly higher amounts of fish oil. There are many programs, websites and tools that can help you quit. Medications can also work differently if they are taken on an empty stomach. The factor V Leiden mutation itself doesnt have any specific treatment.
Review of Factor V Leiden Thrombophilia - U.S. Pharmacist Book: Mayo Clinic Family Health Book, 5th Edition, Newsletter: Mayo Clinic Health Letter Digital Edition. With Factor V Leiden the risk of a blood clot increases with age 0 100 200 300 400 500 600 700 800 900 1000 Risk per 100,000 people Childhood 20's 40's 80's Having 1 Factor V Leiden gene (heterozygous type) slightly increases the chance of developing a blood clot. It is recommended that patients on anticoagulants drink two or fewer alcoholic drinks per day. The heart-healthy Mediterranean diet which includes lots of fruits and vegetables along with healthy fats is a smart choice for those with factor V Leiden. Factor V Leiden may lead to deep vein thrombosis or a pulmonary embolism, which are serious medical emergencies. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation, mask requirements and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. Lockwood CJ, et al. The questions may keep coming, and thats normal. 0000007946 00000 n
(accessed March 04, 2023). Hormones and birth control pills also increase womens risk of blood clots. Learn to recognize the signs of a blood clot so that you can get help as soon as possible. INR values of between 2.0 and 3.0 are considered effective therapeutic values while on anticoagulant therapy. There is also a 50% chance that your child will inherit your normal Factor V gene. Mayo Clinic does not endorse companies or products. 0000002967 00000 n
2. Since then I was also diagnosed w My name is MARTIN R. LEMIEUX, and for over 20 years now Ive survived five DVTS BLOOD CLOTS in my left leg, one clot in my right leg, and another clot in my left pelvic area. 78 0 obj<>stream
This may not be a good choice for those who have to travel a lot for work, have an inflexible schedule, or prefer to eat out, as food prep and timing may be a problem. It is advised that vitamin K intake through diet (chiefly through liver meats, high amounts of green leafy vegetables, and cranberry juice) also be closely monitored in such patients for the same reason.
Most people who inherit it never develop abnormal blood clots, and may never even know they have the disorder.